Personalized Precision Medicine for Space Flight Participants

Space flight is one of the most extreme conditions encountered by humans. Advances in Omics methodologies (genomics, epigenomics, transcriptomics, proteomics, metabolomics, and micriobiomics) have revealed that unique differences exist between individuals. These differences can be amplified in extreme conditions, such as space flight. Examining individual differences in the research setting, allows us to better describe the biological response to space flight conditions.  Examining individual differences in space medicine practice, allows us to develop personalized countermeasure packages that are intended to optimize the safety and performance of individual humans entering space.  This is done with due respect to 1) what is actionable today, 2) what may be actionable in the near term (given more evidence), and 3) what may be actionable in the far term.
At Sovaris Aerospace, we leverage the ability of targeted and untargeted Omics to advance our ability to:
  • More thoroughly describe the biological response of humans in space
  • Describe molecular attributes of individual space flight participants that alter the risk profile prior to entering the space environment
  • Deploy Omics techniques in the development of personalized countermeasures
  • Develop a comprehensive Omics-based assessment and countermeasure platform that will guide human space flight in the future.
It is also our aim at Sovaris to advance the concept of personalized precision medicine in human space flight, with the goal of enhancing human safety and performance. Because the field is vast, we highlight, below, selected examples where knowledge of biochemical individuality might significantly impact space flight countermeasure development. These include gene and small molecule variants associated with:
  • Metabolism of therapeutic drugs used in space
  • One carbon metabolism and DNA stability
  • Iron metabolism, oxidative stress, and DNA stability
  • Essential input (e.g. Mg, Zn, nicotinamide) effects on DNA repair
  • Molecular network changes associated with adverse events in space
  • Molecular dynamics that affect mood, cognition, team cohesion, and other brain-associated attributes
  • Performance dynamics

At Sovaris Aerospace, we believe that widespread Omics profiling should serve as the foundation for aerospace medicine research. As part of our prior and our ongoing work, we develop methodological approaches to advance the field of space medicine research with a continual focus on actionable countermeasures. In addition, we have developed molecular-based assessment and countermeasures that can be deployed today, while recognizing that near- and far-term innovation will continually be required to advance the field.  In this context, we are strongly committed to contributing to the evolution of personalized medicine, as the standard of care for humans in space.

Artificial Neural Network Schema We use to Portray Inputs-Outputs that Shape Metabolic Pathways and Networks

Sample Artificial Neural Network Representation to Visualize Inputs to Molecular Networks